T_Dia
01-29-2010, 11:42 PM
In patients with type 2 diabetes, silent cerebral infarction signaled an increased risk for progressive renal disease and renal failure, independent of microalbuminuria, according to newly published study in the Journal of the American Society of Nephrology.
The study included 608 patients with type 2 diabetes. At baseline, all were free of symptomatic stroke, heart disease or renal disease (overt proteinuria or renal dysfunction). On baseline MRI scans of the brain, 177 of the patients (29%) had silent cerebral infarction — but not severe enough to cause overt symptoms of stroke.
During a mean 7.5 years of follow-up, patients with diabetes and silent cerebral infarction had higher risks for progressive renal disease. Compared with patients with normal brain MRI scans, those with silent cerebral infarction were about 2.5 times more likely to die or develop end-stage renal disease (HR=2.44; 95% CI, 1.36-4.38), the primary outcome. The patients’ risk for declining renal function or dialysis was nearly five times higher.
Patients with silent cerebral infarction also had a significantly higher risk for the secondary endpoint of dialysis or doubling of the serum creatinine concentration (HR=4.79; 95% CI, 2.72-8.46).
Further, the estimated glomerular filtration rate declined more in patients with silent cerebral infarction compared with those without. However, the presence of silent cerebral infarction did not increase the risk for albuminuria progression.
Full Article (http://www.endocrinetoday.com/view.aspx?rid=60487).
The study included 608 patients with type 2 diabetes. At baseline, all were free of symptomatic stroke, heart disease or renal disease (overt proteinuria or renal dysfunction). On baseline MRI scans of the brain, 177 of the patients (29%) had silent cerebral infarction — but not severe enough to cause overt symptoms of stroke.
During a mean 7.5 years of follow-up, patients with diabetes and silent cerebral infarction had higher risks for progressive renal disease. Compared with patients with normal brain MRI scans, those with silent cerebral infarction were about 2.5 times more likely to die or develop end-stage renal disease (HR=2.44; 95% CI, 1.36-4.38), the primary outcome. The patients’ risk for declining renal function or dialysis was nearly five times higher.
Patients with silent cerebral infarction also had a significantly higher risk for the secondary endpoint of dialysis or doubling of the serum creatinine concentration (HR=4.79; 95% CI, 2.72-8.46).
Further, the estimated glomerular filtration rate declined more in patients with silent cerebral infarction compared with those without. However, the presence of silent cerebral infarction did not increase the risk for albuminuria progression.
Full Article (http://www.endocrinetoday.com/view.aspx?rid=60487).