T_Dia
02-04-2010, 05:15 PM
Elevated fasting plasma glucose rates during childhood — even those inside the normoglycemic range — appeared to be a significant predictor of type 2 diabetes in adulthood, according to new study results.
Researchers gathered data from the cross-sectional, long-term Bogalusa Heart Study, which followed participants from childhood to young adulthood (ages 4 to 18 years) for an average 21 years; 1,723 participants were classified as having normoglycemia, 79 prediabetes and 47 diabetes.
The likelihood of developing prediabetes (P<.001) or diabetes (P=.03) in young adulthood was elevated twofold for participants with fasting plasma glucose levels of 86 mg/dL to 99 mg/dL during childhood.
Moreover, this association was “independent of other traditional cardiometabolic risk factors,” according to the researchers.
For the prediction value of the 86 mg/dL threshold, the area under the receiver operating curve analysis yielded a C value of 0.855 for prediabetes and 0.789 for diabetes models. Sensitivity models were 76.9% for prediabetes and 75% for diabetes; specificity models were 85.2% for prediabetes and 76% for diabetes.
Results of a multivariate analysis that factored anthropometric, hemodynamic and metabolic variables indicate that participants with elevated fasting plasma glucose levels during childhood were 3.4 times more likely to develop prediabetes (P<.001) and 2.06 times more likely to develop diabetes (P=.05) in adulthood compared with children without elevated levels.
Full Article (http://www.endocrinetoday.com/view.aspx?rid=60633).
Researchers gathered data from the cross-sectional, long-term Bogalusa Heart Study, which followed participants from childhood to young adulthood (ages 4 to 18 years) for an average 21 years; 1,723 participants were classified as having normoglycemia, 79 prediabetes and 47 diabetes.
The likelihood of developing prediabetes (P<.001) or diabetes (P=.03) in young adulthood was elevated twofold for participants with fasting plasma glucose levels of 86 mg/dL to 99 mg/dL during childhood.
Moreover, this association was “independent of other traditional cardiometabolic risk factors,” according to the researchers.
For the prediction value of the 86 mg/dL threshold, the area under the receiver operating curve analysis yielded a C value of 0.855 for prediabetes and 0.789 for diabetes models. Sensitivity models were 76.9% for prediabetes and 75% for diabetes; specificity models were 85.2% for prediabetes and 76% for diabetes.
Results of a multivariate analysis that factored anthropometric, hemodynamic and metabolic variables indicate that participants with elevated fasting plasma glucose levels during childhood were 3.4 times more likely to develop prediabetes (P<.001) and 2.06 times more likely to develop diabetes (P=.05) in adulthood compared with children without elevated levels.
Full Article (http://www.endocrinetoday.com/view.aspx?rid=60633).