T_Dia
05-04-2009, 02:20 PM
Type 1 diabetes is an autoimmune condition, where the body attacks its own insulin producing cells. It is very serious, with a sudden and dramatic onset, usually in youth. People with Type 1 diabetes must maintain an insulin-monitoring and insulin-injecting regimen for the rest of their lives.
PhD student Eliana Mariņo and Dr Shane Grey, from the Garvan Institute of Medical Research in Sydney, have demonstrated how a particular molecule may be used in future as a preventative therapy. Their findings are published online in the international journal Diabetes.
The body's immune cells, or white blood cells, include B cells and T cells. B cells make antibodies and present 'antigens' to T cells, allowing them to recognise, and kill, invaders.
In previously published studies about Type 1 diabetes, Mariņo and Grey showed that groups of B cells migrate to the pancreas and pancreatic lymph nodes, presenting specific insulin antigen to T cells. In other words, B cells go to the disease site and tell T cells to kill the cells that produce insulin.
"Taking that work further, our current study looks at different ways of subduing B cells, and how that affects development of the disease," said Grey.
Full Article (http://www.sciencedaily.com/releases/2009/04/090429111243.htm).
PhD student Eliana Mariņo and Dr Shane Grey, from the Garvan Institute of Medical Research in Sydney, have demonstrated how a particular molecule may be used in future as a preventative therapy. Their findings are published online in the international journal Diabetes.
The body's immune cells, or white blood cells, include B cells and T cells. B cells make antibodies and present 'antigens' to T cells, allowing them to recognise, and kill, invaders.
In previously published studies about Type 1 diabetes, Mariņo and Grey showed that groups of B cells migrate to the pancreas and pancreatic lymph nodes, presenting specific insulin antigen to T cells. In other words, B cells go to the disease site and tell T cells to kill the cells that produce insulin.
"Taking that work further, our current study looks at different ways of subduing B cells, and how that affects development of the disease," said Grey.
Full Article (http://www.sciencedaily.com/releases/2009/04/090429111243.htm).