T_Dia
03-17-2008, 06:15 PM
A risk score using commonly measured clinical and biochemical variables may help predict mortality in patients with type 2 diabetes mellitus.
Researchers from Hong Kong conducted a prospective cohort study of 7,583 patients with type 2 diabetes enrolled in the Hong Kong Diabetes Registry since 1995. The data was censored on July 30, 2005 or after six years of follow up. Linear-transforming formulas were created using a restricted cubic spline model and the researchers randomly assigned the data to a training or test dataset.
During a median follow-up of 5.51 years, 619 patients died?a mortality rate of 18.69 per 1,000 person-years. Numerous variables, including age, sex and cancer history, were used to create a risk score for all-cause mortality.
Predicted and observed death rates in the test dataset were similar (P>.70), according to the study. The researchers used the risk score to rank cause-specific deaths and found that for genitourinary death, the area under the receiver operating characteristic curve was 0.95; for circulatory death, 0.85; for respiratory death, 0.85; and for neoplasm death, 0.71.
The researchers wrote that additional substantiation is needed before using the risk score in a clinical setting. ? by Stacey L. Adams
Full Article (http://www.endocrinetoday.com/view.aspx?rid=27017).
Researchers from Hong Kong conducted a prospective cohort study of 7,583 patients with type 2 diabetes enrolled in the Hong Kong Diabetes Registry since 1995. The data was censored on July 30, 2005 or after six years of follow up. Linear-transforming formulas were created using a restricted cubic spline model and the researchers randomly assigned the data to a training or test dataset.
During a median follow-up of 5.51 years, 619 patients died?a mortality rate of 18.69 per 1,000 person-years. Numerous variables, including age, sex and cancer history, were used to create a risk score for all-cause mortality.
Predicted and observed death rates in the test dataset were similar (P>.70), according to the study. The researchers used the risk score to rank cause-specific deaths and found that for genitourinary death, the area under the receiver operating characteristic curve was 0.95; for circulatory death, 0.85; for respiratory death, 0.85; and for neoplasm death, 0.71.
The researchers wrote that additional substantiation is needed before using the risk score in a clinical setting. ? by Stacey L. Adams
Full Article (http://www.endocrinetoday.com/view.aspx?rid=27017).